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[av_heading heading=’BRIS.105 – (Senior) Director, Pharmacometrics, Quantitative Pharmacology, and Modeling & Simulation’ tag=’h1′ style=’blockquote modern-quote modern-centered’ size=’32’ subheading_active=” subheading_size=’15’ padding=’10’ color=’custom-color-heading’ custom_font=’#6a8494′]
Chief Executive Officer
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We are seeking a (Senior) Director, Pharmacometrics, Quantitative Pharmacology, and Modeling & Simulation to establish quantitative pharmacology and PK/PD modeling & simulation as a core capability at Unity. The underlying discipline is intended to be a key part of each program’s asset strategy and also to be an integral consideration for platform projects and external collaborations.

This individual will be responsible for the development and use of a variety of approaches for the mechanistic modeling of biological systems, including disease state models, disease progression models, drug-disease models, models of intracellular signaling pathways, cell networks dynamics, and mechanistic PK/PD models. Among the most valuable uses of these methods will be to support the precision medicine goals of Unity to deliver medicines that treat diseases associated with aging to those patients most likely to benefit.

Key technical responsibilities are to develop QSP models in the context of specific molecule or therapeutic area needs to support clinical trials such as dosing, patient selection, biomarker and diagnostic investigation, combination therapy identification and optimization. Other key responsibilities include leading QSP related interactions with cross-functional teams, presenting at team meetings, department meetings, senior management review committees, regulatory interactions, scientific conferences, and writing QSP related sessions such as analysis plans, reports, and regulatory documents. These will be accomplished by working in close partnership with other scientists in Clinical Pharmacology, Preclinical and Translational PK, DMPK, Clinical Science, Biomarker, Diagnostics, Safety Assessment, Biostatistics, Regulatory, and other functions on project teams. Qualified individual could be responsible for overseeing the strategy and implementation of QSP and other M&S activities by other scientists across projects.

Responsibilities

Required Skills

Please send resume to careers@unitybiotechnology.com.
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