Pathological angiogenesis in retinopathy engages cellular senescence and is amenable to therapeutic elimination via BCL-xL inhibition

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https://www.cell.com/cell-metabolism/fulltext/S1550-4131(21)00011-5

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Neutrophil extracellular traps target senescent vasculature for tissue remodeling...UBX1325, a small molecule inhibitor of Bcl-xL, attenuates vascular dysfunction...