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Therapeutic targeting of cellular senescence in diabetic macular edema: preclinical and phase 1 trial results
Crespo-Garcia, et al. Nature Medicine (2024)
Pathological angiogenesis in retinopathy engages cellular senescence and is amenable to therapeutic elimination via BCL-xL inhibition
Crespo-Garcia, et al. Cell Metabolism. (2021)
Neutrophil extracellular traps target senescent vasculature for tissue remodeling in retinopathy
Binet, et al. Science. (2020)
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Therapeutic targeting of cellular senescence in diabetic macular edema: preclinical and phase 1 trial results
Crespo-Garcia, et al. Nature Medicine (2024)
UBX1325, a small molecule inhibitor of Bcl-xL, attenuates vascular dysfunction in two animal models of retinopathy
Crespo-Garcia, et al. Nature Medicine (2021)
Pathological angiogenesis in retinopathy engages cellular senescence and is amenable to therapeutic elimination via BCL-xL inhibition
Crespo-Garcia, et al. Cell Metabolism. (2021)
Neutrophil extracellular traps target senescent vasculature for tissue remodeling in retinopathy
Binet, et al. Science. (2020)
Senolytic therapies for healthy longevity
van Deursen. Science. (2019)
Clearance of senescent glial cells prevents tau-dependent pathology and cognitive decline
Brussian, et al. Nature. (2018)
Cellular Senescence Is Associated With Human Retinal Microaneurysm Formation During Aging
Lopez-Luppo, et al. Invest Ophthalmol Vis Sci. (2017)
Cellular Senescence Is Associated With Human Retinal Microaneurysm Formation During Aging
Blasiak, et al. Oxid Med Cell Longev. (2017)
Senescent cells: an emerging target for diseases of ageing
Childs, et al. Nat Rev Drug Discov. (2017)
Clearance of senescent cells by ABT263 rejuvenates aged hematopoietic stem cells in mice
Chang, et al. Nat Med. (2016)
Senescence-associated secretory phenotype contributes to pathological angiogenesis in retinopathy
Oubaha, et al. Sci Transl Med. (2016)
Naturally occurring p16Ink4a-positive cells shorten healthy lifespan
Baker, et al. Nature. (2016)
Senescent intimal foam cells are deleterious at all stages of atherosclerosis
Childs, et al. Science. (2016)
Cellular senescence and the aging brain
Chinta, et al. Exp Gerontol. (2015)
The role of senescent cells in ageing
van Deursen. Nature. (2014)
Review: a meta-analysis of GWAS and age-associated diseases
Jeck, et al. Aging Cell. (2012)
Clearance of p16Ink4a-positive senescent cells delays ageing-associated disorders
Baker, et al. Nature. (2011)
Senescence-associated secretory phenotypes reveal cell-nonautonomous functions of oncogenic RAS and the p53 tumor suppressor
Coppe, et al. Plos Biology. (2008)
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