Senolytic therapies for healthy longevity
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Tag Archive for: Foundational
Senescent cells: an emerging target for diseases of ageing
https://pubmed.ncbi.nlm.nih.gov/28729727/
Clearance of senescent cells by ABT263 rejuvenates aged hematopoietic stem cells in mice
http://www.nature.com/nm/journal/v22/n1/full/nm.4010.html
Naturally occurring p16Ink4a-positive cells shorten healthy lifespan
http://www.nature.com/nature/journal/v530/n7589/full/nature16932.html
The role of senescent cells in ageing
http://www.nature.com/nature/journal/v509/n7501/full/nature13193.html
Review: a meta-analysis of GWAS and age-associated diseases
https://www.ncbi.nlm.nih.gov/pubmed/22888763
Clearance of p16Ink4a-positive senescent cells delays ageing-associated disorders
http://www.nature.com/nature/journal/v479/n7372/full/nature10600.html
Senescence-associated secretory phenotypes reveal cell-nonautonomous functions of oncogenic RAS and the p53 tumor suppressor
http://journals.plos.org/plosbiology/article?id=10.1371/journal.pbio.0060301