Therapeutic targeting of cellular senescence in diabetic macular edema: preclinical and phase 1 trial results
https://www.nature.com/articles/s41591-024-02802-4
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UBX1325, a small molecule inhibitor of Bcl-xL, attenuates vascular dysfunction in two animal models of retinopathy
https://www.nature.com/articles/s41591-024-02802-4
Pathological angiogenesis in retinopathy engages cellular senescence and is amenable to therapeutic elimination via BCL-xL inhibition
https://www.cell.com/cell-metabolism/fulltext/S1550-4131(21)00011-5
Neutrophil extracellular traps target senescent vasculature for tissue remodeling in retinopathy
https://science.sciencemag.org/content/369/6506/eaay5356.editor-summary
Senolytic therapies for healthy longevity
https://unitybiotechnology.com/wp-content/uploads/JVD-Perspective-Science.pdf
Clearance of senescent glial cells prevents tau-dependent pathology and cognitive decline
https://www.nature.com/articles/s41586-018-0543-y
Cellular Senescence Is Associated With Human Retinal Microaneurysm Formation During Aging
https://iovs.arvojournals.org/article.aspx?articleid=2630798
Local clearance of senescent cells attenuates the development of post-traumatic osteoarthritis and creates a pro-regenerative environment
https://pubmed.ncbi.nlm.nih.gov/28436958/
Cellular Senescence Is Associated With Human Retinal Microaneurysm Formation During Aging
https://www.hindawi.com/journals/omcl/2017/5293258/
Senescent cells: an emerging target for diseases of ageing
https://pubmed.ncbi.nlm.nih.gov/28729727/