FROM MECHANISMS TO POTENTIAL MEDICINES

Our initial focus is on eliminating accumulated senescent cells, which are a fundamental mechanism of aging and a driver of many common age-associated diseases.

Over the arc of one’s life, cells divide until they encounter some form of biologic stress, at which point they pull a form of cellular emergency brake causing them to cease dividing—forever.

The result is an accumulation of senescent cells that secrete large quantities of harmful proteins, which cause inflammation, tissue degradation and the production of growth factors that alter the tissue microenvironment, which we believe leads to several age-associated diseases.

UNITY is developing a number of therapies intended to selectively eliminate senescent cells to halt, slow or reverse age-associated disease and restore tissue to a more functionally healthy state, which we believe addresses a root cause of age-associated diseases.

PUBLICATIONS
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